Protein solutions used for research...

Protein solutions used for research, vaccines, or therapeutics ne to be clear of contaminants. One of the chief disquiets is the presence of endotoxins (lipopolysaccharides) because their removal from protein solutions is a challenge. Typically, removal techniques utilize adsorption onto surfaces of beads in batch reactions, onto beads packed in rounded pillars or onto membrane surfaces.

When poly(e-lysine), generally used as a food preservative, is impregnated into cellulose beads, it can be safely used as a ligand for endotoxin removal using affinity chromatography. Poly(e-lysine)