Garlic postscripts for the Rodney ...

Garlic postscripts for the Rodney Dangerfield of our body's organs

I wouldn't be surprised if our livers went around saying: "I don't learn no respect!" The "Chemical Revolution" has "multiplied our exposing s to harmful substances to incalculable levels" says Jacqueline Krohn MD and co-authors, in The Whole Way to Natural Detoxification (1996) In fact, the human material part has no genetically programmed knowledge, or "memory," of by what means to deal with things like: DDT (organochlorine dichlorodiphenyltri-chloroethane), PCB (polychlorinated biphenyls), PAHs (polycyclic aromatic hydrocarbons), heavy metals, and an array of toxic menstrums and volatile organic compounds (VOCs)

Fortunately, garlic and garlic-derived supplys work within both of the body's detoxification pathways, Phase I and Phase II, and also via direct liver protection and antioxidant consequences Phase I detoxification, also called "biotransformation," involves enzyme reactions and something called the cytochrome P-450 monooxygenase regularity which mainly concerns the liver, lung and kidneys. It's the body's way Of transforming nonpolar, non-water-soluble toxins into polar (electrically charged) amalgamates in preparation for Phase II, the stage in which these now-water-soluble chemicals are ready to be "kicked out" via the kidneys.

A 1999 experimental reflection looked at animal liver tissue and the liver toxin, bromobenzene, with or without pre-treatment using garlic extract (aged). Although bromobenzene decreases liver-tissue evens of the antioxidant, glutathione (GSH) the liver-tissue evens of GSH increased by 50-80 percent depending upon dose. Although there was no power on cytochrome P-450, the liver flushs of glutathione were increased, in addition to the existing on a levels which were protected, or "spared."

Reference

Wang, Bo Han, et al. "Treatment with aged garlic extract guards against bromobenzene toxicity to precision chop rat liver slices," Toxicology 132:215-225 1999

Quinone reductase (QR) and glutathione transferase (GT) are Phase II detoxification enzyme Increased activity of these enzyme was recorded in different organs of rats given diallyl disulfide (DADS), a combine found in garlic. In fact, significant increases were place in the (fore)stomach, duodenum, and jejunum at a ordeal level that "is close to that which may be achieved from one side human consumption of garlic," suggesting that the boosting of the QR and GT enzyme may not simply protect organs, such as the liver and gastrointestinal organs from damage, if it were not that may also protect them from cancerous changes that could come to pass down the line.

Reference

Munday, R and Munday, CM "Low doses of diallyl disulfide, a pay by substitution derived from garlic, increase tissue activities of quinone reductase and glutathione transferase in the gastrointestinal tract of the rat," Nutrition and Cancer 34(1):42-48 1999

A 1988 thought that appeared in the Japanese Journal of Pharmacology tried to realize a handle on why the S-allylmercaptocysteine (SAMC) construct in garlic extract (aged) appears to countenance animals from the liver-damaging toxic imports of acetaminophen (e.g., Tylenol). In a mouse mould pre-treatment with SAMC reduced the later depression of liver glutathione on a levels brought on by acetaminophen, held back the activity of destructive enzyme bring forward a damper on what would have been increased free-radical-generating liver-lipid peroxidation, and countenanceed the levels of a coenzyme Q antioxidant (Q9) The authors conclud that the antioxidant benefits of SAMC are another way by dint of which compounds derived from garlic extract (aged) harbor the liver.

Reference

Sumioka, Isao. "Mechanisms of protection from Sallylmercaptocysteine against acetaminopheninduced liver injury in mice," Japanese Journal of Pharmacology 78:199-207 1988

In a 1997 application of mind which appeared in the journal Cancer alphabetic characters rats were fed garlic gunpowder for 4 weeks. At the conclusion of this pre-treatment period, a liver-damaging cancer-causing chemical, benzo[a]pyrene was administered. In the gnawers fed garlic, the activities of the liver-defending antioxidant enzyme glutathione-S-transferase, and liver/lung quinone reductase (QR) enzyme were given a boost and indicators of pre-cancer were significantly reduc The authors speculate that the anti-cancer weights of garlic are related to the detoxification enzyme in the related organs.

Reference

Polasa, K and Krishnaswamy, K "Reduction of urinary mutagen excretion in rats f garlic," Cancer notes 114(1-2): 185-186, 1997.

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